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  6. Thermo Scientific Chemicals 5-Azacytidine, 99%

Thermo Scientific Chemicals 5-Azacytidine, 99%

Catalog Number ac226620500
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Quantity:
50 mg
1 g
320-67-2
C8H12N4O5
244.21
MFCD00006539
NMUSYJAQQFHJEW-KVTDHHQDSA-N
5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
9444
CHEBI:2038
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
320-67-2
C8H12N4O5
244.21
MFCD00006539
NMUSYJAQQFHJEW-KVTDHHQDSA-N
5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
9444
CHEBI:2038
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

Description

5-Azacytidine, CAS # 320-67-2, is an chemical analog of cytidine that acts as an inhibitor of DNA methyltransferase activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
5-Azacytidine is a chemical analog of the nucleoside cytidine that incorporates into DNA and inhibits DNA methylation
At low doses, 5-azacytidine irreversibly binds the enzyme DNA methyltransferase (DNMT)
Applications
5-Azacytidine has been used for cardiomyocyte differentiation from mesenchymal stem cells
It has been used as a potent DNMT inhibitor in the study of tumor cell proliferation and induction of gene expression following demethylation
5-Azacytidine can globally change histone modification patterns
TRUSTED_SUSTAINABILITY
CAS Min % 98.5
CAS Max % 100.0
Melting Point 228.0°C to 230.0°C
Color White
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (HPLC)
Packaging Glass bottle
Quantity 50 mg
Merck Index 15, 884
Specific Rotation + 40.00
Solubility Information Solubility in water: .. Other solubilities: soluble in methanol
Formula Weight 244.21
Percent Purity 99%
Physical Form Crystalline Powder
Chemical Name or Material 5-Azacytidine, 99%
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Safety and Handling

Hazard Category GHS Signal Word: Danger
Hazard Statement GHS H Statement
Harmful if swallowed.
May cause genetic defects.
May cause cancer.
Precautionary Statement GHS P Statement
IF SWALLOWED: rinse mouth.
Do NOT induce vomiting.
Call a POISON CENTER or doctor/physician if you feel unwell.
Wash face,hands and any exposed skin thoroughly after handling.
Obtain special instructions before us
EINECSNumber 206-280-2
RTECSNumber XZ3017500
SDS

RUO – Research Use Only

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