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5-Fluorouracil, 99%, Thermo Scientific Chemicals
Description
5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.
Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.
Specifications
| Melting Point | ∽282°C (decomposition) |
| Assay Percent Range | 99% |
| Quantity | 5 g |
| UN Number | UN2811 |
| Beilstein | 127172 |
| Sensitivity | Light sensitive |
| Merck Index | 14,4181 |
| Solubility Information | Soluble in dimethylformamide,dimethyl sulfoxide,methanol,hot water,ammonium hydroxide,sodium hydroxide,ethanol and water. |
| Formula Weight | 130.08 |
| Percent Purity | 99% |
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Safety and Handling
| Hazard Category | H301-H312+H332-H315-H319-H335-H341-H361d |
| Hazard Statement | GHS H Statement H360-H341-H373-H302 |
| Precautionary Statement | P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P362-P501c |
| DOTInformation | Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S. |
| EINECSNumber | 200-085-6 |
| RTECSNumber | YR0350000 |
| TSCA | Yes |
| storageNote1 | Air Sensitive |
| Recommended Storage | Ambient temperatures |
RUO – Research Use Only
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