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5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody (59.1), Active Motif™
Mouse Monoclonal Antibody
Supplier: Active Motif 40900
Description
5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.Specifications
5-Hydroxymethylcytosine (5-hmC) | |
Monoclonal | |
1 mg/mL | |
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8 | |
Mouse | |
Protein G | |
RUO | |
Human, Mouse | |
Antibody | |
IgG2a |
ChIP Assay, Dot Blot, Immunoprecipitation | |
59.1 | |
Unconjugated | |
5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2 | |
This 5-Hydroxymethylcytosine antibody was raised against 5-hydroxymethylcytidine conjugated to kLH and recognizes 5-hydroxymethylcytosine. | |
50 μg | |
Primary | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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