5-Hydroxymethylcytosine (5-hmC) Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Active Motif 39792
Description5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2|
|This 5-Hydroxymethylcytidine antibody was raised against 5-hydroxymethylcytidine conjugated to kLH and recognizes 5-hydroxymethylcytosine.|
|Dot Blot, Immunohistochemistry, Immunoprecipitation|
|-20°C, Avoid Freeze/Thaw Cycles|
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