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5-Hydroxymethylcytosine (5-hmC) Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™

Rabbit Polyclonal Antibody

Manufacturer:  Active MotifSupplier Diversity Partner 39092

Encompass

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Catalog No. 50-199-2858


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Description

Description

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
Specifications

Specifications

5-Hydroxymethylcytosine (5-hmC)
1 mg/mL
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2
This 5-Hydroxymethylcytidine antibody was raised against 5-hydroxymethylcytidine conjugated to kLH and recognizes 5-hydroxymethylcytosine.
Protein A
RUO
Antibody
Polyclonal
Dot Blot, Immunohistochemistry, Immunoprecipitation
Unconjugated
Liquid
Rabbit
IgG
50 μg
-20°C, Avoid Freeze/Thaw Cycles
Primary
Human, Mouse
SDS
Documents
Product Certifications
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