Tocris A 740003
Potent and selective P2X7 antagonist
Manufacturer: Tocris 3701/50
DescriptionPotent and selective P2X7 receptor antagonist (IC50 values are 18 and 40nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100µM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.
- Chemical Name: N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
- Formula: C26H30N6O3
- CAS Number: 861393-28-4
- Solubility: Soluble to 20mM in DMSO
- Purity: >98
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