Tocris™ A 740003

Potent and selective P2X7 antagonist

Manufacturer: Tocris™ 3701/50

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Catalog No. 37-015-0R

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For Research Use Only


    Product Type A 740003
    Inhibitors A 740003
    Purity >98
    Molecular Weight 474.55
    Quantity 50mg

    Potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100µM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.

    • Chemical Name: N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
    • Formula: C26H30N6O3
    • CAS Number: 861393-28-4
    • Solubility: Soluble to 20mM in DMSO
    • Purity: >98

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