Tocris A 987306
Potent and selective H4 receptor antagonist
Manufacturer: Tocris 3640/10
DescriptionPotent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3, H1 and H2 receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42µmol/kg, ip).
- Chemical Name: (±)-(7aR*,11aR*)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine
- Formula: C18H25N5O
- CAS Number: 1082954-71-9
- Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
- Purity: >98
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