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A-Raf Mouse anti-Human, Clone: OTI2F8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526614

Catalog No. PIMA526614


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Description

Description

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Specifications

Specifications

A-Raf
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P10398
RP1-230G1.1, A-RAF, ARAF1, PKS2, RAFA1, A-Raf proto-oncogene serine/threonine-protein kinase, Oncogene ARAF1, Ras-binding protein DA-Raf, proto-oncogene A-Raf-1, proto-oncogene Pks, serine/threonine-protein kinase A-Raf, v-raf murine sarcoma 3611 viral oncogene homolog 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
369
Immunohistochemistry (Paraffin), Western Blot
OTI2F8
Unconjugated
ARAF
Liquid
ARAF
Human recombit protein fragment corresponding to amino acids 145-365 of ARAF produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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