Tocris™ A01

High affinity Smurf1 inhibitor; enhances BMP signaling

Manufacturer: Tocris™ 5397/50

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Catalog No. 53-975-0

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For Research Use Only


    Product Type A01
    Inhibitors A01
    Purity >98
    Molecular Weight 512.93
    Quantity 50mg

    High affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

    • Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
    • Formula: C22H20ClF3N4O3S
    • CAS Number: 1007647-73-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

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