High affinity Smurf1 inhibitor; enhances BMP signaling
Manufacturer: Tocris 5397/50
DescriptionHigh affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
- Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
- Formula: C22H20ClF3N4O3S
- CAS Number: 1007647-73-5
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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