Tocris™ A12B4C3

Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor

Manufacturer: Tocris™ 5097/50

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Catalog No. 50-975-0R

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For Research Use Only


    Inhibitors A12B4C3
    Product Type A12B4C3
    Purity >98
    Molecular Weight 534.65
    Quantity 50mg

    Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor (IC50 = 60nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

    • Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
    • Formula: C30H38N4O5
    • CAS Number: 1005129-80-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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