Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor
Manufacturer: Tocris 5097/10
DescriptionPotent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor (IC50 = 60nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.
- Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
- Formula: C30H38N4O5
- CAS Number: 1005129-80-5
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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