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CtIP, Polyclonal, Bethyl Laboratories Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Bethyl Laboratories, IncSupplier Diversity Partner A300488AM

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Catalog No. 50-155-7745


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disruppted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
Specifications

Specifications

CtIP
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
Q80YR6, Q99708
CTIP, RIM
Rabbit
IgG
100 μl
4° C
Primary
225182, 5932
Western Blot
Unconjugated
RBBP8
liquid
RBBP8
Between 850 and C-term
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
SDS
Documents
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