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A4GNT Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI1F7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526434

Catalog No. PIMA526434


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Description

Description

Alpha 1,4-N-acetylflucosaminyltransferase (alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H. pylori infected patients, which suggest the involvement of alpha4Gn-T in defense against H. pylori infection.
Specifications

Specifications

A4GNT
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q14BT6, Q9UNA3
Alpha-1;4-N-acetylglucosaminyltransferase; alpha4GnT; A4GNT; GnTalpha4; alpha4 GnT
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
333424, 485683, 51146, 685758, 716512
Western Blot
OTI1F7
Unconjugated
A4GNT
Liquid
A4gnt
Human recombit protein fragment corresponding to amino acids 121-340 of A4GNT produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Non-human primate, Rat
Documents
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