ABCB1 Mouse anti-Human, Clone: OTI6E4, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF808751
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
|Human recombit protein fragment corresponding to amino acids 995-1280 of human ABCB1 produced in SF9 cell.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1|
|-20° C, Avoid Freeze/Thaw Cycles|
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