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MRP2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549997

Catalog No. PA549997


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Description

Description

The antibody detects endogenous levels of total ABCC2 protein.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Specifications

Specifications

MRP2
Polyclonal
Unconjugated
ABCC2
Liquid
ABCC2
Synthesized peptide derived from internal of human ABCC2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q92887, Q8VI47
ABCC2, CMOAT, CMOAT1, CMRP, MRP2, Canalicular multispecific organic anion transporter 1
Rabbit
IgG
100 μL
-20°C
Primary
1244, 12780
Documents
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