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SUR1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550836

Catalog No. PA550836


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Description

Description

The antibody detects endogenous levels of total ABCC8 protein.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal domit disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
Specifications

Specifications

SUR1
Polyclonal
Unconjugated
ABCC8
Liquid
ABCC8
Synthetic peptide corresponding to residues near the C terminal of human ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.2 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q09428
HI, SUR, HHF1, MRP8, PHHI, SUR1, ABC36, HRINS, TNDM2, SUR1delta2
Rabbit
IgG
100 μL
-20°C
Primary
6833
Documents
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