ABH1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA589613

Catalog No. PIPA589613

Description

Immunogen sequence: YQWHWVKQCL KLYSQKPNVC NLDKHMSKEE TQDLWEQSKE FLRYKEATKR RPRSLLEKLR WVTVGYHYNW DSKKYSADHY TPFPSDLGFL SEQVAAACGF EDFRAEAGIL NYYRLDSTLG IHVDRSELDH SKPLLSFSFG QSAIFLLGGL QRDEAPTAMF MHSGDIMIMS GFSRLLNHAV PRVLPNPEGE GLPHCLEAPL PAVLPRDSMV EPCSMEDWQV CASYLKTARV NMTVRQVLAT DQNFPLEPIE DEKRDISTEG FCHLDDQNSE VKRARINPDS; Positive Samples: 293T; Cellular Location: Mitochondrion, Nucleus

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.

Specifications

• Antigen: ABH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALKBH1
• Gene Symbols: ALKBH1
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 110-389 of human ALKBH1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunofluorescence, Immunoprecipitation, Western Blot
• Concentration: 4.47 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q13686
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8846
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid