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ABH1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA589613

Catalog No. PIPA589613


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Description

Description

Immunogen sequence: YQWHWVKQCL KLYSQKPNVC NLDKHMSKEE TQDLWEQSKE FLRYKEATKR RPRSLLEKLR WVTVGYHYNW DSKKYSADHY TPFPSDLGFL SEQVAAACGF EDFRAEAGIL NYYRLDSTLG IHVDRSELDH SKPLLSFSFG QSAIFLLGGL QRDEAPTAMF MHSGDIMIMS GFSRLLNHAV PRVLPNPEGE GLPHCLEAPL PAVLPRDSMV EPCSMEDWQV CASYLKTARV NMTVRQVLAT DQNFPLEPIE DEKRDISTEG FCHLDDQNSE VKRARINPDS; Positive Samples: 293T; Cellular Location: Mitochondrion, Nucleus

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ABH1
Polyclonal
Unconjugated
ALKBH1
2700073G19Rik, Abh, ABH1, alkB, alkB homolog 1, histone H2A dioxygenase, alkB, alkylation repair homolog 1, alkB, alkylation repair homolog 1 (E. coli), ALKBH, Alkbh1, Alkylated DNA repair protein alkB homolog 1, alkylation repair, alkB homolog, alpha-ketoglutarate-dependent dioxygenase ABH1, DNA 6mA demethylase, DNA demethylase ALKBH1, DNA lyase ABH1, DNA N6-methyl adenine demethylase, DNA N6-methyl adenine demethylase ALKBH1, DNA oxidative demethylase ALKBH1, hABH, mRNA N(3)-methylcytidine demethylase, Nucleic acid dioxygenase ALKBH1, tRNA N1-methyl adenine demethylase
Rabbit
Affinity Chromatography
RUO
8846
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Immunocytochemistry, Immunoprecipitation, Western Blot
1.01 mg/mL
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Q13686
ALKBH1
Recombinant fusion protein containing a sequence corresponding to amino acids 110-389 of human ALKBH1 (NP_0060112)
100 μL
Primary
Human
Antibody
IgG
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