Tocris™ AC 710

Potent and selective PDGFR family inhibitor

Manufacturer: Tocris™ 5013/10

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Catalog No. 50-131-0RD

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For Research Use Only


    Specifications

    Description AC 710
    Molecular Weight 562.7
    Purity >99
    Quantity 10mg
    Product Type AC 710

    Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

    • Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
    • Formula: C31H42N6O4
    • CAS Number: 1351522-04-7
    • Solubility: Soluble to 20mM in DMSO
    • Purity: >99

  • Description & Specifications

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