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Tocris™ AC 710

Potent and selective PDGFR family inhibitor

Manufacturer:  Tocris™ 5013/10

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Catalog No. 50-131-0RD


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For Research Use Only


Specifications

Description

Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
  • Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
  • Formula: C31H42N6O4
  • CAS Number: 1351522-04-7
  • Solubility: Soluble to 20mM in DMSO
  • Purity: >99
Description & Specifications

Specifications

AC 710
>99
AC 710
562.7
10mg
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