Tocris AC 710
Potent and selective PDGFR family inhibitor
Manufacturer: Tocris 5013/10
DescriptionPotent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
- Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
- Formula: C31H42N6O4
- CAS Number: 1351522-04-7
- Solubility: Soluble to 20mM in DMSO
- Purity: >99
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok