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ACAP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 201351AP

Catalog No. 50-173-2721



Description

Description

ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
Specifications

Specifications

ACAP1
0.18 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q15027, Q8K2H4
ACAP1, Centaurin beta 1, CENTB1, Cnt b1, KIAA0050
Rabbit
IgG
150 μL
-20°C
Primary
216859, 287443, 9744
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
ACAP1
Liquid
Acap1
ACAP1 Fusion Protein Ag14068
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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