ACD Mouse anti-Human, Clone: OTI1C8, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA504201

Catalog No. 50-167-4937

Description

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Specifications

• Antigen: ACD
• Classification: Monoclonal
• Concentration: 0.72 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q96AP0
• Gene Alias: PIP1, PTOP, TINT1, TPP1
• Host Species: Mouse
• Isotype: IgG2b
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 65057

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI1C8
• Conjugate: Unconjugated
• Gene: ACD
• Format: Liquid
• Gene Symbols: ACD
• Immunogen: Full length human recombit protein of human ACD produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human