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ACD Mouse anti-Human, Clone: OTI1A2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525904

Catalog No. PIMA525904



Description

Description

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Specifications

Specifications

ACD
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96AP0
PIP1; PTOP; TINT1; TPP1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
65057
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI1A2
Unconjugated
ACD
Liquid
ACD
Full length human recombit protein of ACD produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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