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Acetyl-CoA Carboxylase Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA524700

Catalog No. PIMA524700


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Description

Description

This antibody reacts to human Acetyl CoA Carboxylase 1. This antibody may also react to mouse or rat Acetyl CoA Carboxylase 1, as predicted by immunogen homology. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5 ft. sequence and encoding distinct isoforms have been found for this gene.
Specifications

Specifications

Acetyl-CoA Carboxylase
Recombinant Monoclonal
Unconjugated
ACACA
Liquid
ACACA
Peptide corresponding to humAcetyl CoA Carboxylase 1.
Protein A
RUO
Antibody
Monoclonal
Human
Immunohistochemistry, Western Blot
RM232
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4
Q13085
ACAC; ACACA; ACC-alpha; ACC1; ACCA; Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase-alpha; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
31
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