MilliporeSigma™ Acetyl-CoA Synthetase, Mouse, Unlabeled, Clone: 6C1.2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS1720

Catalog No. MABS1720MI

Description

Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1; UniProt Q9NR19; also known as Acetate-CoA ligase, Acetyl-CoA synthetase, AceCS, ACS, Acyl-activating enzyme, Acyl-CoA synthetase short-chain family member 2) is encoded by the ACSS2 (also known as ACAS2) gene (Gene ID 55902) in human. ACS plays a vital role in prokaryotic and eukaryotic cells by activating acetate to form acetyl CoA that serves as a source of two carbon metabolite for lipid synthesis and energy producing reactions. It is also reported to play a role in gene expression. In yeast cells it delivers acetyl CoA for histone acetylation. ACS contributes to cancer cell growth under low-oxygen and lipid-depleted conditions and its expression is upregulated under metabolically stress. Silencing ACSS2 gene is shown to reduce the growth of tumor xenografts. Ref.: Starai, VJ., and Escalante-Semerena, JC. (2004). Cell. Mol. Life Sci. 61, 2020 2030. Schug, ZT et al. (2015). Cancer Cell. 27:57-71.

Specifications

• Antigen: Acetyl-CoA Synthetase
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: Q9NR19
• Immunogen: GST-tagged recombinant human acetyl-CoA synthetase N-terminal fragment.
• Quantity: 100 μg
• Research Discipline: Signaling
• Gene ID (Entrez): NP_061147
• Target Species: Human
• Form: Purified

• Applications: Western Blot
• Clone: 6C1.2
• Conjugate: Unconjugated
• Gene: ACSS2, ACAS2
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Immunogen sequence is present in both spliced isoforms of human acetyl-CoA synthetase reported by UniProt (Q9NR19).
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG2a κ

For Research Use Only. Not for use in diagnostic procedures.