Acetyl-Histone H2B (Lys20) Rabbit anti-Human, Non-human primate, Invitrogen
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Invitrogen MA524698
This antibody reacts to Histone H2B acetylated at Lysine 20 (K20ac). No cross reactivity with non-modified Lysine 20 or other acetylated Lysines in histone H2B. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The nucleosomes wrap further and compact DNA into chromotin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones play a central role in transciption regulation, DNA repair, DNA replication, and chromosomal stability. H2B has a broad antibacterial activity.
|Acetyl-Histone H2B (Lys20)|
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4|
|H2B histone family, member F; H2B/f; H2B/I; H2BFA; H2BFH; H2BFL; H2BK5ac; HIST1H2BC; histone 1, H2bb; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; Histone H2B.I|
|-20° C, Avoid Freeze/Thaw Cycles|
|337873, 337874, 440689, 8339, 8346, 8349|
|ChIP assay, ELISA, Immunocytochemistry, Immunofluorescence, Peptide Array, Western Blot|
|HIST1H2BG, HIST1H2BI, HIST2H2BC, HIST2H2BD, HIST2H2BE, HIST2H2BF|
|Acetyl-peptide corresponding to Acetyl-Histone H2B (Lys20).|
|Human, Non-human primate|
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