Histone H3 (K36M Mutant) Rabbit anti-Human, Invitrogen
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Invitrogen MA524680
This antibody reacts to the Histone H3 K36M mutant. No cross reactivity with wild type Histone H3. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.Histone H3 is one of the four core proteins of the nucleosome, and it is involved in transcription regulation, DNA repair, DNA replication and chromosomal stability. The N-terminal tail of Histone H3 undergoes many post-translational modifications, including phosphorylation, acetylation, multiple methylation, ubiquitination, and ADP-ribosylation to achieve its diverse functions. HistoneH3 is acetylated and deacetylated on N-terminal lysine residues. Acetylation removes the positive charge on the histone, decreasing the interaction with the negatively charged phosphate groups of DNA, and resulting in a more relaxed structure associated with greater levels of gene transcription. Acetylation of histone H3 at lysine 9 (H3K9Ac) is one of the most well-known epigenetic markers enriched in the promoter region of activated genes.
|Histone H3 (K36M Mutant)|
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4|
|H3 histone family, member A; H3a; H3K9ac; HIST1H3A; Histone 1; histone 1, H3a; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l|
|-20° C, Avoid Freeze/Thaw Cycles|
|ChIP assay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|Peptide corresponding to Acetyl-Histone H3 (Arg36).|
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