Acetyl-Histone H4 (Lys12) Mouse anti-Human, Clone: 3HH4-4C10, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA3058
MA3-058 detects Acetyl-Histone H4 Lys12 in Human samples. MA3-058 has been succesfully used in western blot and ELISA applications. Immunogen is a synthetic peptide corresponding to residues 1-24 of Human Acetyl-Histone H4 Lys12, which is highly conserved across multiple species.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
|Acetyl-Histone H4 (Lys12)|
|Synthetic peptide corresponding to amino acids 1-24 of human Histone H4 coupled to ovalbumin: MSGRG(acetyl-K)GG(acetyl-K) GLG(acetyl-K)GGA(acetyl-K)RHRKVLR-C|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|ascites with 0.05% sodium azide|
|H4FA, H4K12ac, H4K12a|
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