Invitrogen™ ACTA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578716

Catalog No. PIPA578716

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human placenta tissue, human Hela whole cell, human HepG2 whole cell, human 293T whole cell, human A431 whole cell, human U87 whole cell, human U937 whole cell, human K562 whole cell, rat heart tissue, rat brain tissue, rat kidney tissue, mouse heart tissue, mouse brain tissue, mouse spleen tissue, mouse kidney tissue. IHC: human breast cancer tissue, human colorectal adenocarcinoma tissue, human placenta tissue, human tonsil tissue, mouse heart tissue, rat heart tissue.

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.

Specifications

• Antigen: ACTA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACTA1
• Gene Alias: AA959943; ACTA; Acta1; Acta-2; actin alpha 1; actin alpha 1, skeletal muscle; actin, alpha 1, skeletal muscle; actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; Acts; Actsk-1; alpha actin 1; alpha-actin-1; ASMA; beta actin; CFTD; CFTD1; CFTDM; cytoplasmic beta-actin; LOW QUALITY PROTEIN: actin, alpha skeletal muscle; MPFD; NEM1; NEM2; NEM3; nemaline myopathy type 3; SHPM; skeletal alpha actin; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11459, 29437, 58
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P68133, P68134, P68136
• Gene Symbols: ACTA1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Actin (359-377aa ITKQEYDEAGPSIVHRKCF).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG