ACVRL1 Mouse anti-Human, Clone: OTI5C2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527180
DescriptionThe TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombit human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, TGF-B superfamily receptor type I, activin A receptor, type II-like kinase 1, activin receptor-like kinase 1, serine/threonine-protein kinase receptor R3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 22-119 of ACVRL1 produced in E.coli|
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