ADAMTS4 Mouse anti-Human, Clone: OTI2G8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805430

Catalog No. 50-166-7423

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Specifications

• Antigen: ADAMTS4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ADAMTS4
• Gene Alias: ADAMTS-2, ADAMTS-4, ADMP-1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9507
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2G8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O75173
• Gene Symbols: ADAMTS4
• Immunogen: Human recombit protein fragment corresponding to amino acids 296-577 of human ADAMTS4 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1