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ADAR Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549815

Catalog No. PA549815


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Description

Description

The antibody detects endogenous levels of total ADAR protein.

ADAR catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities.
Specifications

Specifications

ADAR
Polyclonal
Unconjugated
ADAR
Liquid
ADAR
Synthesized peptide derived from C-terminal of human ADAR1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P55265, Q99MU3
136 kDa double-stranded RNA binding protein, ADAR1, DRADA, DSH, DSRAD
Rabbit
IgG
100 μL
-20°C
Primary
103, 56417
Documents
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