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Adenosine Deaminase Mouse anti-Human, Clone: CL0176, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524586

Catalog No. PIMA524586


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Description

Description

Immunogen sequence: SDNQPEGMIS ESLDNLESMM PNKVRKIGEL VRYLNTNPVG GLLEYARSHG FAAEFKLVDQ SGPPHEPKFV YQAKVGGRWF PAVCAHSKKQ GKQEAADAAL RVLIGENEKA ERMGFTEVTP VTGASLRRTM LLLSRSPEA Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.

ADAR catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities.
Specifications

Specifications

Adenosine Deaminase
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P00813
RP11-61L14.5, ADAR1, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136, 136 kDa double-stranded RNA-binding protein, adenosine deaminase acting on RNA 1-A, double-stranded RNA-specific adenosine deaminase, dsRNA adenosine deaminase, interferon-induced protein 4, interferon-inducible protein 4
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100
Immunohistochemistry, Western Blot
CL0176
Unconjugated
ADA
Liquid
ADA
Recombit protein corresponding to Human Adenosine Deaminase
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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