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alpha-2b Adrenergic Receptor Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549610

Catalog No. PA549610


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Description

Description

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
Specifications

Specifications

alpha-2b Adrenergic Receptor
Polyclonal
PBS with 0.09% sodium azide
P18089
Alpha-2B adrenergic receptor, Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor, Alpha-2BAR, ADRA2B, ADRA2L1, ADRA2RL1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
151
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
ADRA2B
Liquid
ADRA2B
KLH conjugated synthetic peptide between 343-369 amino acids from the Central region of human ADRA2B.
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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