ADRA2B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 197781AP
The antibody is specific to ADRA2B.Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P18089, P19328, P30545|
|ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, Alpha 2B adrenergic receptor, Alpha 2B adrenoceptor, Alpha 2B adrenoreceptor, Alpha 2BAR, ALPHA2BAR|
|11552, 151, 24174|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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