ADSL Mouse anti-Canine, Cynomolgus Monkey, Human, Rat, Clone: OTI2D10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525263
DescriptionADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Adenylosuccinate lyase; ASL; Adenylosuccinase; Asase; ADSL; AMPS|
|-20° C, Avoid Freeze/Thaw Cycles|
|158, 315150, 474499, 709259|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ADSL produced in HEK293T cell|
|Canine, Cynomolgus Monkey, Human, Rat|
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