Tocris™ AEG 40730 dihydrochloride

IAP antagonist; induces apoptosis

Manufacturer: Tocris™ 5330/50

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Catalog No. 53-305-0

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For Research Use Only


    Specifications

    Description AEG 40730 dihydrochloride
    Molecular Weight 1120.06
    Purity >98
    Quantity 50mg
    Product Type AEG 40730 dihydrochloride

    IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

    • Chemical Name: 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride
    • Formula: C52H68F6N8O8.2HCl
    • Solubility: Soluble to 100mM in water and to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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