Ago1/2/3 Monoclonal Antibody (2A8), Active Motif™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-2980	Active Motif 39938	10 μg
50-199-2979	Active Motif 39937	100 μg

Description

The Argonaute family of proteins play roles in RNA interference and in short-interfering-RNA-mediated gene silencing. Small interfering RNAs (siRNAs) have gained much attention for their powerful ability to suppress gene expression. Introduction of double-stranded RNA (dsRNA), that are homologues in sequence to a gene, has proven to suppress that gene's expression through a process known as RNA interference (RNAi); this process post-transcriptionally silences a gene through mRNA inhibition or degradation. Both biochemical and genetic studies have led to the identification of two, conserved gene families that are universal components of the interference process. These are the Dicer family, which is comprised of members of the Ribonuclease III family of enzymes, and the Argonaute gene family. Argonaute proteins addition to their role in RNAi process, may also influence development, such as, stem cell fate determination.

Specifications

• Antigen: Ago1/2/3
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene ID (Entrez): 192669, 26523, 27161
• Immunogen: This Ago1/2/3 antibody was raised against a recombinant protein corresponding to amino acids 47-859 of human Ago2.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: AGO2

• Clone: 2A8
• Applications: Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: Q9H9G7, Q9UKV8, Q9UL18
• Gene Symbols: AGO1, AGO2, AGO3
• Isotype: IgG
• Purification Method: Protein G
• Product Type: Antibody