Argonaute 1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550654
The antibody detects endogenous levels of total AGO1 protein.Small interfering RNAs (siRNAs) have gained much attention for their powerful ability to suppress gene expression. Introduction of double-stranded RNA (dsRNA), that are homologues in sequence to a gene, has proven to suppress that gene ft.s expression through a process known as RNA interference (RNAi); this process post-transcriptionally silences a gene through mRNA inhibition or degradation. Both biochemical and genetic studies have led to the identification of two, conserved gene families that are universal components of the interference process. These are the Dicer family, which is comprised of members of the Ribonuclease III family of enzymes, and the Argonaute gene family. Argonaute proteins addition to their role in RNAi process, may also influence development, such as, stem cell fate determination.
|Synthetic peptide corresponding to a region derived from internal residues of human argonaute RISC catalytic component 1|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.05% sodium azide; pH 7.3|
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