AHNAK Monoclonal Antibody (EM-09), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA110050

Catalog No. PIMA110050

Description

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predomitly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.

Specifications

• Antigen: AHNAK
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Gene: AHNAK
• Gene Alias: AHNAKRS, MGC5395, AHNAK-related, desmoyokin, neuroblast differentiation-associated protein AHNAK
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 66395, 79026
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Clone: EM-09
• Conjugate: Unconjugated
• Gene Accession No.: Q09666
• Gene Symbols: AHNAK
• Immunogen: Bacterially expressed fragment of N-terminal domain of human AHNAK1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1