Tocris™ AI-3

ARE activator; induces Nrf2-ARE-dependent transcription

Manufacturer: Tocris™ 5145/10

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Catalog No. 51-451-0

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For Research Use Only


    Product Type AI-3
    Inhibitors AI-3
    Purity >98
    Molecular Weight 292.8
    Quantity 10mg

    Antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.

    • Chemical Name: 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
    • Formula: C11H13ClO3S2
    • CAS Number: 882288-28-0
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >98

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