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AIPL1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 151081AP

Catalog No. 50-172-9985


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Description

Description

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
Specifications

Specifications

AIPL1
0.21 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q924K1, Q9JLG9, Q9NZN9
AIPL1, AIPL2, LCA4
Rabbit
IgG
150 μL
-20°C
Primary
114230, 23746, 59110
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
AIPL1
Liquid
Aipl1
AIPL1 Fusion Protein Ag4625
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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