Invitrogen™ ALDH18A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114385

Catalog No. PIPA5114385

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human MDA-MB-453 whole cell, human Caco-2 whole cell, human HEK293 whole cell, rat heart tissue, mouse skeletal muscle tissue . Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Specifications

• Antigen: ALDH18A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALDH18A1
• Gene Alias: 2810433K04Rik; ADCL3; AI429789; aldehyde dehydrogenase 18 family member A1; aldehyde dehydrogenase 18 family, member A1; aldehyde dehydrogenase 18A1; aldehyde dehydrogenase family 18 member A1; aldh18a1; ARCL3A; cb842; cb899; delta1-pyrroline-5-carboxlate synthetase; delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthetase; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GK; Glutamate 5-kinase; glutamate gamma-semialdehyde synthetase; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GPR; GSAS; MGC117316; P5CS; Pycs; pyrroline-5-carboxylate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase); sb:cb881; similar to pyrroline-5-carboxylate synthetase isoform 1; SPG9A; SPG9B; wu:fa91f10; wu:fi05f11; wu:fi17d12
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361755, 56454, 5832
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Western Blot, Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: P54886, Q9Z110
• Gene Symbols: ALDH18A1
• Immunogen: E.coli-derived human P5CS/ALDH18A1 recombinant protein (Position: M1-A224).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov