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ALDH2 Mouse anti-Human, Clone: OTI4H2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524969

Catalog No. PIMA524969


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Description

Description

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Specifications

Specifications

ALDH2
Monoclonal
0.6 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P05091
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); ALDH-E2; ALDHI; ALDM; MGC1806; ALDH class 2; acetaldehyde dehydrogenase 2; liver mitochondrial ALDH; mitochondrial aldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Mouse
IgG3
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
217
Flow Cytometry, Immunocytochemistry, Immunofluorescence
OTI4H2
Unconjugated
ALDH2
Liquid
ALDH2
Full length human recombit protein of ALDH2 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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