ALK Mouse anti-Human, Clone:8E8D3, Abnova
Mouse monoclonal antibody raised against recombinant human ALK.
Manufacturer: Abnova Corporation MAB17856
DescriptionThe 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3 ft. half of ALK, derived from chromosome 2, is fused to the 5 ft. portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq]
|anaplastic lymphoma receptor tyrosine kinase|
|In PBS (0.05% sodium azide)|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ELISA, Flow Cytometry, Western Blot|
Flow Cytometry (1:200-400)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.
|CD246, Ki-1, TFG/ALK|
|Recombinant protein corresponding to amino acids 1366-1468 of human ALK from E. coli.|
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