ALK Mouse anti-Human, Clone: OTI2E4, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF801308
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOThe 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3 ft. half of ALK, derived from chromosome 2, is fused to the 5 ft. portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
|Human recombit protein fragment corresponding to amino acids 1300-1620 of human ALK produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|-20° C, Avoid Freeze/Thaw Cycles|
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