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ALK Mouse anti-Human, Clone: OTI5G1, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF801744

Catalog No. 50-166-5713


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3 ft. half of ALK, derived from chromosome 2, is fused to the 5 ft. portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Specifications

Specifications

ALK
Monoclonal
Unconjugated
ALK
Lyophilized
ALK
Full length human recombit protein of human ALK produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI5G1
PBS with 8% trehalose and no preservative; pH 7.3
Q9UM73
CD246, NBLST3
Mouse
IgG2b
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
238
SDS
Documents
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