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ALK Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Thermo Scientific MA533093

Catalog No. PIMA533093


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Description

Description

Specificity: reacts to human total ALK protein including ALK fusion proteins. Recombit rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombit rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3′ half of ALK, derived from chromosome 2, is fused to the 5′ portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Specifications

Specifications

ALK
Recombinant Monoclonal
Unconjugated
ALK
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
Human
Immunohistochemistry, Western Blot
RM361
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Q9UM73
ALK
A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase).
Protein A
RUO
Antibody
238
SDS
Documents
Product Certifications
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