Alkaline Phosphatase, Intestinal Mouse, Clone: SPM372, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2479950.2MG

Catalog No. NBP247995B

Description

Alkaline Phosphatase, Intestinal Monoclonal antibody specifically detects Antigen in Human, Primate samples. It is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen).

Specifications

• Antigen: Alkaline Phosphatase, Intestinal
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Dilution: Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
• Gene Alias: alkaline phosphatase, intestinal, alkaline phosphomonoesterase, EC 3.1.3.1, glycerophosphatase, IAP, Intestinal alkaline phosphatase, intestinal-type alkaline phosphatase, Kasahara isozyme
• Host Species: Mouse
• Molecular Weight of Antigen: 55 kDa
• Quantity: 0.2 mg
• Research Discipline: Cancer, Embryonic Stem Cell Markers, Lipid and Metabolism, Protein Phosphatase, Stem Cell Markers
• Gene ID (Entrez): 248
• Target Species: Human, Primate
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunofluorescence, CyTOF
• Clone: SPM372
• Conjugate: Unconjugated
• Formulation: PBS with No Preservative
• Gene Symbols: ALPI
• Immunogen: Bovine intestinal alkaline phosphatase
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Isotype: IgG1 κ