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ALOX5 Mouse anti-Human, Clone: OTI2C5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526828

Catalog No. PIMA526828


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Description

Description

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Specifications

Specifications

ALOX5
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P09917
arachidonate 5-lipoxygenase; RP11-67C2.3; ALOX5; ALOX5; 5-LO; 5LPG; LOG5 ; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
240
Immunohistochemistry (Paraffin), Western Blot
OTI2C5
Unconjugated
ALOX5
Liquid
ALOX5
Human recombit protein fragment corresponding to amino acids 18-364 of ALOX5 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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