Alpha A Crystallin Mouse anti-Bovine, Human, Mouse, Rat, Clone: 1H3.B8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527582
DescriptionLens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintece. Alpha-B crystallin has been linked to Alexander ft.s disease where it accumulates in brain cells of those afflicted.
|Alpha A Crystallin|
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.2|
|P02470, P24622, P24623|
|Heat shock protein beta4, Acry 1, CRYA1, CRYAA, HSPB4|
|102724652, 12954, 24273, 281718|
|ELISA, Immunocytochemistry, Immunofluorescence, Western Blot|
|Native Alpha Crystallin|
|Bovine, Human, Mouse, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok