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Alpha A Crystallin Mouse anti-Bovine, Human, Mouse, Rat, Clone: 1H3.B8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527582

Catalog No. PIMA527582


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Description

Description

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintece. Alpha-B crystallin has been linked to Alexander ft.s disease where it accumulates in brain cells of those afflicted.
Specifications

Specifications

Alpha A Crystallin
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.2
P02470, P24622, P24623
Heat shock protein beta4, Acry 1, CRYA1, CRYAA, HSPB4
Mouse
IgG1
200 μg
-20°C
Primary
102724652, 12954, 24273, 281718
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
1H3.B8
Unconjugated
CRYAA2
Liquid
CRYAA, CRYAA2
Native Alpha Crystallin
Protein G
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Rat
Documents
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