alpha-actinin (Actinin alpha 1) Mouse anti-Human, Clone: OTI7A4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500072

Catalog No. 50-165-9341

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: alpha-actinin (Actinin alpha 1)
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ACTN1
• Gene Alias: BDPLT15
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 87
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI7A4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P12814
• Gene Symbols: ACTN1
• Immunogen: Human recombit protein fragment corresponding to amino acids 650-893 of human alpha-actinin produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a